New Publication on Signature of Intestinal Barrier Loss

Second Genome’s Microbiome Signature Discovery services have been cited in a new publication in the prestigious journal Mucosal Immunology. The Kaetzel laboratory at the University of Kentucky College of Medicine  found that major microbiome composition changes occurred in the intestine of mice with a deletion of a critical signaling molecule involved in maintaining the intestinal [...]

Oral microbiome, Periodontitis

The oral microbiome contains over 600 species of microbiota. Under normal conditions the predominant phyla are Firmicutes, Bacteriodetes, Proteobacteria, Actinobacteria, and Fusobacteria. The most abundant bacterial genera in the oral microbiome are members of the genus Streptococcus, but Abitrophia, Gemella, Granulicatella, and Prophyromonas are also extremely common. P. gingivalis is often present in the oral [...]

Gut Microbiome, Allergies

The “hygiene hypothesis” suggests that the increase in allergic and autoimmune diseases such as asthma, allergic rhinitis (hayfever), and multiple sclerosis in developed countries is linked to a decline in infectious burden that causes an immune imbalance. One particular theory is that certain infectious agents that co-evolved with us, including probiotics such as Lactobacillus, are protective [...]

Gut Microbiota and Neurologic Inflammation

The gut microbiota can have far-reaching effects on the body, not only playing a role in gut pathology, such as inflammatory bowel disease, but also other conditions including asthma, and stress-related memory problems. In our fourth post detailing research presented at the National Academy of Sciences “Microbes and Health” colloquium we examine the potential role [...]