Unlocking the potential of the microbiome is at the core of Second Genome's drug discovery efforts. Our research and development is focused on applying microbiome science to host biology to discover and develop more effective therapeutic options for patients.

Second Genome Pipeline


Inflammatory bowel disease (IBD) is a diverse disease of unknown etiology resulting in more frequent and bloody bowel movements accompanied with histopathological damage to the gastrointestinal mucosa. While specific triggers of disease remain poorly defined, one proposal of disease progression suggests that a breakdown of intestinal barrier function allows bacteria or bacterial components to translocate into mucosal tissue. Bacterial translocation results in activation of inflammatory signaling, which triggers additional barrier disruption, resulting in a cyclic amplification loop of barrier disruption, bacterial translocation and inflammation. While many current therapies target inflammation, the lack of therapies promoting mucosal healing provides an opportunity for novel therapies promoting epithelial repair and intestinal barrier integrity. Similar biology underlies the pathological problem seen in oral mucositis, a side of effect of chemotherapy and radiation therapy in cancer patients. Oral mucositis is a debilitating disease with a high unmet need.

SG-2-0776 is a novel therapeutic protein derived from the microbiome that promotes mucosal healing of damaged epithelial surfaces. SG-2-0776 is currently in pre-clinical and IND-enabling studies, and we plan to initiate clinical studies in 2020