Metatranscriptomic Profiling

Characterizing the specific expression profiles of the microbes at time of sample collection, this research tool provides the most robust approach for exploring microbiome function in our discovery platform. This solution can provide insight into the subset of genes required for a microbial community to survive, and when used in comparative analysis it can identify key functions and pathways that differentiate one community from another; potentially unlocking the role of microbiome in driving different clinical phenotypes.

Our Analysis

Our goal is to establish the relative abundance of enzymes and pathways for each community. Following this mapping effort, we obtain an assessment of community-level pathway similarity or dissimilarity across all study groups. Assuming that microbial communities with similar pathway representation share similar ecology, this assessment can inform the broader function of the community. Differentially represented pathways are also highlighted to inform which pathways are over or underrepresented in the experimental groups.