SG-3-06686 overview

SG-3-06686 binds to CXCR3 receptor on dendritic cells, amplifies the natural ligand which induces a robust immune cell migration to the tumor microenvironment, ultimately resulting in tumor shrinkage.

Microbiome comparison between anti-PD-1 nonresponders and responders

image description
image description

Anti-PD-1
non-responders

image description
image description

Anti-PD-1
responders

image description image description

Identify peptide
enriched in anti-PD-1
responders

image description

Engineered
SG-3-6686
peptide

image description

SG-3-6686 peptide binds to CXCR3 receptor on dendritic cells

image description

Amplifies natural ligand inducing robust immune cell migration to tumor microenvironment

image description

Tumor shrinkage with single agent and in combination with anti-PD-1 in vivo

Tumor shrinkage in non-responders

image image

SG-3-06686 targets recruitment of immune cells

image image